Regulation of Dedifferentiation of the Schwann Cell in Axonal Regeneration
This custom scientific journal illustration was created for Dr. Nikolaos Tapinos, MD, PhD, Director of Neurosurgery Research at the Geisinger Clinic to accompany his research grant, journal article and be placed on his neurosurgery webpage.
The primary focus of the illustration is the Lck (lymphoid cell kinase) driven pathway which regulates the dynamic changes of the Schwann cell during myelination, migration, differentiation and dedifferentiation. Schwann cells are unusual in the fact that they possess the ability to dedifferentiate back into a more immature stage if the nerve axon they are myelinating is somehow damaged. This ability to dedifferentiate, migrate and myelinate is critical to the regrowth of damaged peripheral nervous system innervations. Understanding this pathway was paramount to being able to tie it into the structure of the Schwann cell itself, and show how the arrangement of the Schwann cell changes as it transforms.
This was a challenging illustration to create with complicated elements which needed to be accurately and clearly illustrated for scientific research purposes. A thorough understanding of how the Lck pathway works as well as the structure and behavior of the Schwann cell in situ was very important. After the scientific aspect of the illustration had been worked out, the magic happened when that knowledge was wrapped into a dynamic, interesting illustration that would captivate the viewer and make them want to read more about it. The end result was a client who was very happy with the finished illustration that we created for his research article.
Image type: Vector – Adobe Illustrator
Original size: 8.5″ x 6″
Resolution: 300 DPI for print
Key Elements of image:
- Schwann Cells in different stages of dedifferentiation.
- Lck (lymphoid cell kinase) driven pathway
“Thank you very much for all your work. I really like the illustration, it is both captivating and scientifically accurate at the same time. It was very nice working with you.”
– from Dr. Nikolaos Tapinos MD, PhD,
Director of Neurosurgery Research
This image is not available for purchase.